|JessiePew||Дата: Пятница, 24.01.2014, 12:51 | Сообщение # 1|
After multiple doses of Theophylline, steady-state is reached in 30 to 65 hours (average 40 hours) in adults. At steady-state, on a dosage regimen with 6-hour intervals, the expected mean trough concentration is approximately 60% of the mean peak concentration, assuming a mean Theophylline half-life of 8 hours. The difference between peak and trough concentrations http://theophylline-online.over-blog.com/2014/01/order-theophylline.html - order theophylline is larger in patients with more rapid Theophylline clearance. In patients with high Theophylline clearance and half-lives of about 4 to 5 hours, such as children age 1 to 9 years, the trough serum Theophylline concentration may be only 30% of peak with a 6-hour dosing interval. In these patients a slow-release formulation would allow a longer dosing interval (8 to 12 hours) with a smaller peak/trough difference.
Special Populations (see Table I for mean clearance and half-life values)